Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Encephalopathy
ADR ID BADD_A01462
ADR Hierarchy
17      Nervous system disorders
17.13      Encephalopathies
17.13.02      Encephalopathies NEC
17.13.02.001      Encephalopathy
Description A disorder characterized by a pathologic process involving the brain. [CTCAE] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM. [MeSH]
MedDRA Code 10014625
MeSH ID D001927
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Encephalopathy | Encephalopathy acute | Encephalopathy chronic | Encephalopathy NOS | Encephalopathy, unspecified | Influenza encephalopathy | Brain Diseases | Brain Disease | Brain Disorders | Brain Disorder | Intracranial CNS Disorders | Central Nervous System Intracranial Disorders | CNS Disorders, Intracranial | CNS Disorder, Intracranial | Intracranial CNS Disorder | Encephalon Diseases | Encephalon Disease | Intracranial Central Nervous System Disorders | Central Nervous System Disorders, Intracranial | Encephalopathies
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Dihydropyrimidine dehydrogenase [NADP(+)]Q12882T75890
Gamma-aminobutyric acid receptor subunit beta-1P15431Not Available
TransketolaseP29401T67754
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01120Ibuprofen0.000037%
BADD_D01133Ifosfamide0.007726%
BADD_D01136Imatinib--
BADD_D01166Interferon alfa-2a--
BADD_D01167Interferon alfa-2b--
BADD_D01194Irbesartan0.000603%
BADD_D01201Isavuconazonium sulfate--
BADD_D01204Isoniazid0.095554%
BADD_D01213Isotretinoin--
BADD_D01221Ivermectin0.080004%
BADD_D01223Ixazomib--
BADD_D01238Lacosamide0.020111%
BADD_D01243Lamotrigine0.002835%
BADD_D01252Leflunomide0.002066%
BADD_D01253Lenalidomide--
BADD_D01254Lenvatinib0.003463%
BADD_D01258Leucovorin0.005831%
BADD_D01265Levetiracetam0.006665%
BADD_D01275Levofloxacin0.001213%
BADD_D01295Linezolid0.018867%
BADD_D01300Lisinopril0.000156%
BADD_D01303Lithium carbonate0.003680%
BADD_D01318Lorazepam0.000738%
BADD_D01369Mefloquine--
BADD_D01370Mefloquine hydrochloride--
BADD_D01376Melphalan0.001598%
BADD_D01378Memantine0.000576%
BADD_D01379Memantine hydrochloride--
BADD_D01392Mercaptopurine0.003849%
BADD_D01393Meropenem0.000213%
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